Aceclofenac 100mg + Paracetamol 325mg + Serratiopeptidase 15 mg Salt Information :
It is prescribed for fever, various kinds of pain and arthritis .
Paracetamol: Nausea, allergic reactions, skin rashes, acute renal tubular necrosis.
Aceclofenac: Diarrhoea, headache, vertigo, dizzies, nervousness, tinnitus, depression, drowsiness, insomnia; fever, angioedema, bronchospasm, rashes; blood dyscrasias.
Potentially Fatal: Paracetamol: Very rare, blood dyscrasias (eg, thrombocytopaenia, leucopaenia, neutropaenia, agranulocytosis); liver damage. Aceclofenac: Severe GI bleeding; nephrotoxicity.
Paracetamol: Reduced absorption of cholestyramine within 1 hr of administration. Accelerated absorption with metoclopramide.
Aceclofenac: May increase the plasma concentrations of lithium and digoxin. Increased nephrotoxicity with diuretics. Serum-potassium should be monitored when used with potassium-sparing diuretics. May enhance activity of anticoagulants. May increase plasma methotrexate levels leading to toxicity if administered within 2-4 hr of methotrexate admin. Risk of convulsions with quinolones.
Potentially Fatal: Paracetamol: Increased risk of liver damage in chronic alcoholics. Increased risk of toxicity with high doses or long term admin of barbiturates, carbamazepine, hydantoins, isoniazid, rifampin and sulfinpyrazone.
Hypersensitivity. Moderate to severe renal or hepatic impairment; severe heart failure; pregnancy (third trimester).
Aceclofenac is a phenylacetic acid derivative that inhibits synthesis of the inflammatory cytokines interleukin-1b and tumour necrosis factor, and inhibits prostaglandin E2 production. It increases glycosaminoglycans (GAG) synthesis, the principal macromolecule of the extracellular matrix, which aids in repair and regeneration of articular cartilage. Thus, aceclofenac has +ve effects on cartilage anabolism combined with modulating effect of matrix catabolism.
Paracetamol has analgesic and antipyretic action with weak anti-inflammatory activity. It produces analgesia by increasing pain threshold and antipyresis by acting on the hypothalamic heat-regulating centre.
Absorption: Aceclofenac: Rapidly absorbed; almost 100% bioavailability; peak plasma levels reached about 1.25-3 hr after oral admin.
Distribution: Aceclofenac: >99.7% bound to plasma proteins; distributes into synovial fluid. Paracetamol: Distributes throughout most fluids of the body.
Metabolism: Aceclofenac: Probably metabolised by CYP2C9; average plasma elimination half-life: 4-4.3 hr. Paracetamol: Mainly metabolised hepatically; plasma elimination half-life: 1-4 hr.
Excretion: Aceclofenac: About two-thirds of the administered dose is removed in the urine, mainly as conjugated hydroxymetabolites. Paracetamol: Most metabolites are removed in the urine within 24 hr.
GI disease; renal or hepatic impairment; alcohol-dependent patients; asthma or allergic disorders; haemorrhagic disorders; hypertension; cardiac impairment. Elderly. Caution when driving or operating machinery. Monitor renal and hepatic function and blood counts during long term treatment. Persistently elevated hepatic enzyme levels may require drug withdrawal. Pregnancy, lactation
Acetaminophen (USP) or paracetamol (INN), an acetanilide, is an analgesic and anti-pyretic drug indicated for temporary relief of fever and minor ache/pain.
Analgesia & feverOral
Analgesia & feverOral<12 y
IV2–12 y, ≥13 y, <50 kg
≥13 y, >50 kg
Postimmunization pyrexia Oral
Renal impairmentModerate renal failure (GFR 10–50 mL/min)
Severe renal failure (GFR <10 mL/min) :
Acetaminophen is a centrally acting analgesic and antipyretic with minimal anti-inflammatory properties. It reduces pain by inhibiting the central prostaglandin synthesis, specifically COX-2 and an elevation of the pain threshold. It reduces fever by inhibiting the release of prostaglandins in the CNS and by inhibition of endogenous pyrogens at the hypothalamic thermoregulatory centers.
Monitor hepatic and renal function
Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID's) used for the management of pain and inflammation in various arthritis conditions. In addition to anti-inflammatory action, it has analgesic, antipyretic and platelet-inhibitory actions.
Ankylosing spondylitis, osteoarthritis, & rheumatoid arthritisOral
Aceclofenac is a nonsteroidal phenyl acetic acid derivative similar to Diclofenac. Like other NSAIDS, Aceclofenac is a COX inhibitor that decreases prostaglandin and leukotriene production, therefore inhibiting the inflammatory process.
Frequency not defined
It is a proteolytic enzyme (protease) produced by enterobacterium Serratia sp. used for painful conditions including back pain, osteoarthritis, rheumatoid arthritis, osteoporosis, fibromyalgia, carpel tunnel syndrome, migraine headache, and tension headache. It is also used for conditions that involve pain and swelling (inflammation) including sinusitis, laryngitis, sore throat, ear infections, swelling after surgery, swelling of a vein with the formation of a blood clot (thrombophlebitis), and inflammatory bowel disease (IBD) including ulcerative colitis and Crohn's disease. Some people use serrapeptase for heart disease and “hardening of the arteries” (atherosclerosis). Women use it for non-cancerous lumpy breasts (fibrocystic breast disease), and nursing mothers use it for breast pain caused by too much milk (breast engorgement). Other uses include treatment of diabetes, leg ulcers, asthma, and pus accumulation (empyema).
Inflammation & Edema
Serratiopeptidase helps to break down the protein which inturn helps to decrease inflammation and mucous.
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