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LEVONAK-M TABLETS

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LEVONAK-M TABLETS

Montelukast+Levocetirizine- a combined therapy is prescribed for the systemic treatment of allergic reactions such as chronic urticaria, obstructive airway diseases and rhinitis. Montelukast belongs to leucotriene receptor antagonist.


Precautions-  It is contraindicated in patients with an allergy to either or both drugs, hepatic impairment, NSAID allergy, Churg-Strauss syndrome. It is contraindicated in children less than six months of age.
It can cause dizziness. Do not drive vehicles or operate heavy machineries that need alertness.


Other Drug Interactions- It may interact with phenytoin, CNS depressants, rifampicin, prednisone and phenobarbital.


Other Interactions- Do not consume alcohol while taking Montelukast + Levocetirizine


Dosage- For treatment of allergic rhinitis and chronic asthma (Adults): Consider administration of 10 mg once a day in the evening. For Prophylaxis of exercise-induced asthma (Adults): Consider administration of 10 mg of Montelukast + Levocetirizine, at least two hours before exercise.

List of Contraindications

Pregnancy- Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women, or animalreproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the first trimester (and there is no evidence of a risk in later trimesters). Montelukast + Levocetirizine may not cause harm to an unborn foetus. Before Montelukast treatment, the patient should discuss with the physician, if they are planning for a pregnancy.


Lactation- It is unclear whether the drug could pass through the breast milk to a breast feeding baby. Consult your physician before taking Montelukast + Levocetirizine, if you are nursing mother.
 

LEVOCETRIZINE-


Indications- Allergic rhinitis, chronic urticaria.Antiallergics and Drugs used in Anaphylaxis


Dose 

Oral

Rhinitis, chronic urticaria: Adult & children

(>12 years) - 5 mg once daily in the evening.

Children (6-12 yrs) - 2.5 mg once daily.

Children (6 months - 5 yrs) – 1.25 mg oncedaily.

Contraindications Hypersensitivity, end-stage renal disease with creatinine clearance < 10 ml/min. Not recommended for lactating mothers or children below 6 months.

Precautions May impair the ability to drive or operate machinery, concurrent use of alcohol or CNS depressant drugs should be avoided,

pregnancy-Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women, or animalreproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the first trimester (and there is no evidence of a risk in later

trimesters), 

elderly, 

interactions-Alcohol or CNS depressants Additive sedation,Theophylline Increases the levels of levocetirizine in blood.


Adverse Effects- Somnolence, fatigue, dry mouth, nasopharyngitis have been reported in adults. Fever, cough, epistaxis and diarrhoea may occur in children <12 years.


Storage Store protected from heat, light and moisture at a temperature not exceeding 30⁰C.


MONTELUKAST-


Indications- Prophylaxis of mild to moderate asthma.


Dose- Oral

Adult- 10 mg once a day.

Child- 2-5yrs: 4 mg once daily; 6-14 yrs: 5 mg

once daily; ≥ 15 yrs: 10 mg once daily.


Contraindications- Hypersensitivity.


Precautions- History of liver disease, 

pregnancy-Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women, or animalreproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the first trimester (and there is no evidence of a risk in later trimesters).


Adverse Effects- Headache; rashes; eosinophilia; neuropathy; Churg-strauss syndrome.


Storage Store protected from light and moisture.