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PENAK-DSR is a combination of 40 mg of Pantoprazole sodium and 30 mg of Domperidone. PENAK DSR is used for the treatment of gastroesophageal reflux disease (GERD), non ulcerative dyspepsia, gastritis, dyspepsia, and duodenal or gastric ulcer. PENAK DSR 40 mg + 30 mg is manufactured by GARNAK Pharma. It is available in time-release tablet and capsule form. PENAK DSR is packaged in blister packs and is available in various pack sizes.The active ingredients contained in Pantocid DSR work together to relieve the symptoms of GERD, heartburn, erosive esophagitis, ulcers, gastritis, and Zollinger-Ellison Syndrome and it decreases the incidence of stomach upset and vomiting by limiting the amount of acid produced by the stomach.

Warnings and Precautions-

While taking PENAK DSR it is important to follow your doctor's instructions. Do not start, stop, or change the dosage without consulting with your doctor. You should not take PENAK DSR if you are allergic to pantoprazole sodium or domperidone or any of its ingredients.If you forget to take a dose take as soon as you remember; if it is close to the time for the next dose, skip the dose and take the next one at the scheduled time. Do not take an extra dose to make up for the missed one.If you accidently take an overdose of PENAK DSR get immediate medical attention. Symptoms of an overdose or allergic reaction include:

  • Wheezing
  • Chest pain
  • Fever
  • Sever cough
  • Gray or blue skin color
  • Seizures
  • Swelling of face, mouth, tongue, or throat
  • Rapid heartbeat
  • Extreme dizziness
  • Loss of consciousness

Avoid alcohol consumption while taking PENAK DSR. Do not use PENAK DSR if it is past the expiration date.PENAK DSR may cause dizziness. Do not drive or operate machinery until you know how it affects you. PENAK DSR should be stored in a cool, dry location, out of the reach of children and pets.

Drug Interactions-

Tell your doctor what other medications you are taking or using, this includes all prescription, over-the-counter, and herbal remedies, to avoid a drug interaction. Do not take PENAK DSR if you take medications such as

  • HIV/AIDS medications
  • Ketoconazole or erythromycin

If you take warfarin or coumadin, PENAK DSR can intensify their affect causing bleeding. This is not a complete list of drugs that may interact with PENAK DSR. Ask your doctor or pharmacist for a complete list.
Take PENAK DSR as prescribed by your doctor. The usual dosage is one tablet or capsule once or twice a day, your doctor will determine the proper dosage for you.To achieve full effect, it should be taken 30 minutes before eating.  Take the time-release tablet or capsule with a full glass of water. Do not break, chew, or crush the tablet or capsule.

Possible Side Effects-

There is the potential for side effects with most medications. If you experience any unusual symptom or an allergic reaction to pantoprazole sodium or domperidone get immediate medical attention. Symptoms of an allergic reaction include:

  • Difficulty breathing
  • Difficulty swallowing
  • Rapid heartbeat
  • Skin rash
  • Swelling of face, tongue, or throat
  • Swelling of feet, ankles or hands

You may experience side effects such as:

  • Anxiety
  • Diarrhea
  • Dry mouth
  • Headache
  • Itching
  • Sleepiness
  • Tender breasts
  • Weakness

Contact your doctor immediately if you experience any of the side effects. Get immediate medical attention if the symptoms continue or gets worse. This is not a complete list of possible side effects. Ask your doctor or pharmacist for a more in-depth list of possible side effects.


Indications- Duodenal ulcer, gastric ulcer, GERD, erosive esophagitis.



Adult- 40 mg once daily up to 8 weeks.


Adult- 40 mg twice daily.

Contraindications- Hypersensitivity.


Hepatic impairment; monitor liver function; 

pregnancy-  Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women, or animal reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the first trimester (and there is no evidence of a risk in later trimesters); cyanocobalamin deficiency; tumorogenicity.

Adverse Effects- Diarrhoea; pruritus; dizziness; pyrexia; blurred vision; vertigo.


Nausea and vomiting from any cause in adult, epigastric senses of fullness; upperabdominal distress; non ulcer dyspepsia; migraine.



Adult- 10 to 20 mg 3 to 4 times a day

Child- 0.3 to 0.6 mg/kg TDS.


Hypersensitivity; prolactinoma, hepatic impairment; where increased gastrointestinal motility harmful; pregnancy; gastro intestinal haemorrhage; intestinal obstruction.


Children; renal impairment,

interactions-Additive toxicity with amiodarone; history of breast cancer;allergies; pheochromocytoma; i.v. administration can lead to hypokalaemia and cardiac arrhythmias.

Adverse Effects-

Rarely, gastro-intestinal disturbances (including cramps) and hyperprolactinaemia;very rarely, extrapyramidal effects and rashes; headache; dizziness; dry mouth; nervousness; flushing.

Storage Store protected from light and moisture.